Review Series MULTIPLE MYELOMA: FROM THE BENCH TO BEDSIDE New criteria for response assessment: role of minimal residual disease in multiple myeloma
نویسندگان
چکیده
Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada, Pamplona, Spain; Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands; and Cancer Research Center Instituto de Biologia Celular y Molecular del Cancer-Consejo Superior de Investigaciones Cient́ıficas/ University of Salamanca, Department of Medicine Cytometry Service, and Instituto Biosanitario de Salamanca, University of Salamanca, Salamanca, Spain
منابع مشابه
In vitro Effect of Pomalidomide on Bone Marrow Mononuclear Cells from Multiple Myeloma Patients
Background: Many features of anticancer drugs, including cytotoxicity and/or cytokine induction, are studied using cell lines orhuman blood leukocytes. However, in a disease such as multiple myeloma, most cancerous cells are resided within bone marrowmononuclear cells. In the present study, we investigated the effect of pomalidomide on apoptosis and IL-2 production of bonemarrow mononuclear cel...
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Introduction: Utilizing lower limit of bone marrow plasma cells (BMPCs) is the main existing criterion for diagnosis of multiple myeloma (MM). According to the revised international myeloma working group (IMWG) diagnostic criteria, the value of 10% is agreed among experts as the cutoff level for diagnosis. Symptomatic patients with BMPC above this value are identified as definite cases of MM. H...
متن کاملStudy of Multiple Myeloma Occurrence in Patients With 5%-10% Bone Marrow Plasma Cells: A Case Series Regarding Revised IMWG Diagnostic Criteria
Introduction: Utilizing lower limit of bone marrow plasma cells (BMPCs) is the main existing criterion for diagnosis of multiple myeloma (MM). According to the revised international myeloma working group (IMWG) diagnostic criteria, the value of 10% is agreed among experts as the cutoff level for diagnosis. Symptomatic patients with BMPC above this value are identified as definite cases of MM. H...
متن کاملMinimal Residual Disease Assessment in the Context of Multiple Myeloma Treatment
With contemporary therapeutic strategies in multiple myeloma, heretofore unseen depth and rate of responses are being achieved. These strategies have paralleled improvements in outcome of multiple myeloma patients. The integration of the next generation of proteasome inhibitors and antibody therapeutics promise continued improvements in therapy with the expectation of consistent depth of respon...
متن کاملNew criteria for response assessment: role of minimal residual disease in multiple myeloma.
Assessment of minimal residual disease (MRD) is becoming standard diagnostic care for potentially curable neoplasms such as acute lymphoblastic leukemia. In multiple myeloma (MM), the majority of patients will inevitably relapse despite achievement of progressively higher complete remission (CR) rates. Novel treatment protocols with inclusion of antibodies and small molecules might well be able...
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تاریخ انتشار 2015